Vitamin D intake during the COVID-19 pandemic and health impacts: a systematic review
Keywords:
vitamin D, COVID-19 pandemic, health impactsAbstract
During the COVID-19 pandemic, vitamin D consumption was highly indicated by the actions on the immune system. This study describes vitamin D intake during the COVID-19 pandemic and its impact on health through systematic review, following the Prisma method. Five databases were used (PubMed, BVS, Scopus, CAPES and Embase). Of the 163 articles found, 11 were selected after eligibility criteria. Nine associated vitamin D deficiency with COVID-19, one assessed vitamin D administration in survivor rate and one analyzed the amount and values of vitamin D acquisition. Vitamin D levels in the pandemic are lower, as is exposure to the sun, the main form of vitamin synthesis. Studies have shown lower levels in more severe cases and greater need for non-invasive ventilation. Further studies of high levels of evidence are recommended.
Downloads
References
Oliveira V, Lara GM, Lourenço ED, Boff BD, Stauder GZ. Influência da vitamina D na saúde humana. Acta Bioquím Clín Latinoam. 2014 set. [citado 19 set 2022]; 48(3):339-347. Disponível em: http://www.scielo.org.ar/pdf/abcl/v48n3/v48n3a07.pdf.
Li Y, Tong CH, Bare LA, Devlin JJ. Assessment of the Association of Vitamin D Level With SARS-CoV-2 Seropositivity Among Working-Age Adults. JAMA Network Open. 2021 [cited 2023 jan. 30]; 4(5). doi: https://dx.doi.org/10.1001/jamanetworkopen.2021.11634.
Teixeira TM, Costa, CL. The role of vitamin D in systemic lúpus erythematosus. Rev. Nutr. 2012 jul./ago. [cited 2022 set. 11]; 25(4):531-538. doi: https://dx.doi.org/10.1590/S1415-52732012000400010.
Modesto MJ, Lacerda L. Vitamin D suplementation: effect on the 25(OH)D profile and occurrence of muscle injuries in professional soccer athletes. Rer. Bras. Med. Esporte. 2021 [cited 2022 set. 12]; 27(6):540-544. Available from: https://www.scielo.br/j/rbme/a/HQgfgzBNFV6HnpVJ4Pzrp9M/?format=pdf.
Melo JRR, Duarte EC, Moraes MV, Fleck K, Arrais PSD. Automedicação e uso indiscriminado de medicamentos durante a pandemia da COVID-19. Cad. Saúde Pública. 2021 [citado 2022 set. 12]; 37(4). doi: https://dx.doi.org/10.1590/0102-311X00053221.
Kaya MO, Pamukçu E, Yakar B. The role of vitamin D deficiency on COVID-19: a systematic review and meta-analysis os observational studies. Epidemiol. Health. 2021 set 23 [cited 2022 set. 12]; 43. doi: https://dx.doi.org/10.4178/epih.e2021074.
Valle CAR, Pedri LAF, Pires GB, Blanco MS, Paula BS, Araújo CDM. Influence of Hypovitaminosis D on the Ocurrence of Fractures. Work developed at the Department of Orthopedics and Traumatology. Rer. Bras. Ortop. 2021 [cited 2022 out. 10]; 56(6):784-789. doi: https://dx.doi.org/10.1055/s-0041-1729585.
Marques CDL, Dantas AT, Fragoso TS, Duarte ÂLBP. A importância dos níveis de vitamina D nas doenças autoimunes. Rer. Bras. Reumatol. 2010 fev. [citado2022 out. 10]; 50(1):67-80. doi: https://dx.doi.org/10.1590/S0482-50042010000100007.
Lim K, Thadhani R. Vitamin D Toxicity. J. Bras. Nefrol. 2020 [cited 2022 out. 10]; 42(2):238-244. doi: https://dx.doi.org/10.1590/2175-8239-JBN-2019-0192.
Galvão TF, Pansani TSA, Harrad D. Principais itens para relatar Revisões sistemáticas e Meta-análises: A recomendação PRISMA. Epidemiol. Serv. Saúde. 2015 jun. [citado 2022 set. 24]; 24(2):335-342. Disponível em: https://www.scielo.br/j/ress/a/TL99XM6YPx3Z4rxn5WmCNCF/?lang=pt .
Ministério da Saúde (Brasil). Departamento de Ciência e Tecnologia. Diretrizes Metodológicas: Elaboração de revisão sistemática e metanálise de estudos observacionais comparativos sobre fatores de risco e prognóstico. Brasília: Ministério da Saúde; 2014.
Medeiros LR, Stein A. Níveis de evidência e graus de recomendação da medicina baseada em evidências. Rer. Amrigs. 2002 [citado 2023 mar. 16]; 46(1,2):43-46.
Adami G, Giollo A, Fassio A, Benini C, Bertoldo E, Bertoldo F, et al. Vitamin D and disease severity in coronavirus disease 19 (COVID-19). Reumatismo. 2020 [cited 29 jan. 2023]; 72(4):189-196. doi: https://dx.doi.org/10.4081/reumatismo.2020.1333.
Curiel MD, Cabello A, Pinel RA, Mansur JL, Frades SH, Fernandez IM, et al. The relationship between 25(OH) vitamin D levels and COVID-19 onset and disease course in Spanish patients. J. Steroid. Biochem. Mol. Biol. 2021 jun. 06 [cited 29 jan. 2023]; 212. doi: https://dx.doi.org/10.1016/j.jsbmb.2021.105928.
Malinowska J, Gieldowska MM, Bankowska D, Borecka K, Ciepiela O. Hypermagnesemia and hyperphosphatemia are highly prevalent in patients with COVID-19 and increase the risk of death. Int. J. Infect. Dis. 2022 [cited 2023 jan. 30]; 122:543-549. doi: https://dx.doi.org/10.1016/j.ijid.2022.06.057.
Baktash V, Hosack T, Patel N, Shah S, Kandiah P, Abbeele KVD, et al. Vitamin D status and outcomes for hospitalised older patients with COVID-19. Postgrad. Med. J. 2020 jul. [cited 2023 jan. 30]; 97(1149): 442-447. doi: http://dx.doi.org/10.1136/postgradmedj-2020-138712.
Elham AS, Azam K, Azam J, Mostafa L, Nasrin B, Marzieh N. Serum vitamin D, calcium, and zinc levels in patients with COVID-19. Clin. Nutr. Espen. 2021 jun. [cited 2023 jan. 30]; 43:276-282. doi: https://dx.doi.org/10.1016/j.clnesp.2021.03.040.
Jude EB, Ling SF, Allcock R, Yeap BXY, Pappachan JM. Vitamin D Deficiency Is Associated With Higher Hospitalization Risk From COVID-19: A Retrospective Case-control Study. J. Endocrinol. Metab. 2021 nov. 11 [cited 2023 jan. 30]; 106(11):4708-4715. doi: https://dx.doi.org/10.1210/clinem/dgab439.
Katz J, Yue S, Xue W. Increased risk for COVID-19 in patients with vitamin D deficiency. J. Nutr. 2021 abr. [cited 30 jan. 2023); 84. doi: https://dx.doi.org/10.1016/j.nut.2020.111106.
Li B, Wang M, Zhou L, Wen Q, Zou J. Association between serum vitamin D and chronic rhinosinusitis: a meta-analysis. Braz. J. Otorhinolaryngol. 2021 [cited 2022 set. 11]; 87(2). doi: https://dx.doi.org/10.1016/j.bjorl.2019.08.007.
Macaya F, Paeres CE, Valls A, Ortiz AF, Castillo JG, Sánchez FJM, et al. Interaction between age and vitamin d deficiency in severe covid-19 infection. Nutr. Hosp. 2020 out. [cited 2023 jan. 30]; 37(5):1039-1042. doi: https://dx.doi.org/10.20960/nh.03193.
Fiore V, Vito A, Bagella P, Princic E, Mariani AA, Denti L, et al. Effectiveness of Vitamin D Supplements among Patients Hospitalized for COVID-19: Results from a Monocentric Matched-Cohort Study. HEALTHC (Amst). 2022 may [cited 2023 jan. 30]; 10(5). doi: https://dx.doi.org/10.3390/healthcare10050956.
Paim NA, Gnatta D. Drug Purchases’s analysis for COVID-19 treatment in Rio Grande do Sul. Rer. Bras. Farm. Hosp. Serv. Saúde. 2021 [cited 2023 jan. 30]; 12(2):554. doi: https://dx.doi.org/10.30968/rbfhss.2021.122.0554.
Silverthorn DU. Fisiologia Humana. 7a. ed. Porto Alegre: Artmed; 2017.
Aguilera J, Gálvez MV, Aguilera P, Troya M, Gilaberte Y. Recomendações sobre exposição solar e fotoproteção do Grupo Español de Fotobiologia da AEDV adequadas ao período de desconfinamento durante a pandemia por SARS-CoV-2. Actas Dermosifiliogr. 2020 [citado 2023 mar. 10]; 111(9):799-801. doi: https://dx.doi.org/10.1016/j.ad.2020.06.001.
Oliveira MAP, Parente RCM. Estudos de Coorte e de Caso-Controle na Era da Medicina Baseada em Evidência. Bras. J. Video-Sur. 2010 [citado 2023 mar. 10]; 3(3):115-125.
Llie PC, Stefanescu S, Smith L. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging. Clin. Exp. Res. 2020 [cited 2023 fev. 28]; 32(7):1195-1198. doi: https://dx.doi.org/10.1007/s40520-020-01570-8.
Kuba k, Imai Y, Penninger JM. Angiotensin-converting enzyme 2 in lung disease. Curr. Opin. Pharmacol. 2006 [cited 2023 mar. 10]; 6(3):271-276. doi: https://dx.doi.org/10.1016/j.coph.2006.03.001.
Murai IH, Fernandes AL, Sales LP, Pinto AJ, Goessler KF, Duran CS, et al. Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial. JAMA. 2021 [cited 2023 mar. 17]; 325(11):1053-1060. doi: https://dx.doi.org/10.1001/jama.2020.26848.
Jolliffe DA, Stefanidis C, Wang Z, Kermani NZ, Dimitrov V, White JH, et al. Vitamin d metabolism is dysregulated in asthma and chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2020 [cited 2023 mar. 17]; 202(3):371-382. doi: https://dx.doi.org/10.1164/rccm.201909-1867OC.
Castanhola ME, Piccinin A. Impact of macrophage gene expression on immunological mechanisms of SARS-CoV-2 infection. Braz. J. Dev. 2022 [cited 2023 mar. 17]; 8(3):18029-18036. doi: https://dx.doi.org/10.34117/bjdv8n3-169.
Reijven PLM, Soeters PB. Vitamin D: A magic bullet or a myth? Clin. Nutr. 2020 [cited 2023 mar. 17]; 39(9):2663-2674. doi: https://dx.doi.org/10.1016/j.clnu.2019.12.028.
Szarpak L, Filipiak KJ, Gasecka A, Gawel W, Koziel D, Jaguszewski MJ, et al. Vitamin D supplementation to treat SARS-CoV-2 positive patients. Evidence from meta-analysis. Cardiol. J. 2022 [cited 2023 abr. 13]; 29(9):188-196. doi: https://dx.doi.org/10.5603/CJ.a2021.0122.
Tazinazzo R, Moreno VG, Ortiz MAL. O aumento do uso de Vitamina D durante a pandemia – dados coletados de uma rede de drogarias na cidade de Maringá – PR. Braz. J. Dev. 2021 [citado 2023 abr. 24]; 7(6):56497-56506. doi: https://dx.doi.org/10.34117/bjdv7n6-181.
Downloads
Published
Issue
Section
License
Os artigos submetidos à revista Colloquium Vitae estão licenciados conforme CC BY-NC-ND. Para mais informações sobre essa forma de Licenciamento, consulte: http://creativecommons.org/licenses/by-nc-nd/4.0/.
A disponibilização é gratuita na Internet, para que os usuários possam ler, fazer download, copiar, distribuir, imprimir, pesquisar ou referenciar o texto integral dos documentos, processá-los para indexação, utilizá-los como dados de entrada de programas para softwares, ou usá-los para qualquer outro propósito legal, sem barreira financeira, legal ou técnica.