INTERAÇÃO DO LAPACHOL COM NANOPLATAFORMAS MICELARES DRUG DELIVERY
Palavras-chave:
Lapachol, Pluronic®, Naftoquinona, Constante de ligação.Resumo
Este artigo contempla aspectos relacionados a capacidade de interação e monomerização do fármaco lapachol com os sistemas nanoestruturados micelares F127 e P123. Para isso, estudos prévios de agregação foram conduzidos para descrição da dinâmica agregacional do princípio ativo e sua influência nas propriedades espectroscópicas. A proposta deste trabalho é enriquecer o arsenal terapêutico atual com um novo formulado descrito pelo elevado potencial antimalárico, antitripanossômico, analgésico e antitinflamatório.
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